Yeah You Can But It Needs Major Help
So i Would Suguest That You Get An EQ Pedal
And Learn To Use The Basics
# 1 Smileing Face > Mouth
More Bass And Treble And Less Mids
Just As The Face Shows
# 2 Frown Less Bass And Treble And More Mids
Just As The Face Shows Again
Now With That Said
An EQ Pedal Before Your Amp
You Can Use One Or The Other Too
Make a Humbucker Sound Like a Single Coil
Or Make a Single Coil Sound Like a Humbucker
If You 2 Guitars With Differnt Picks In Them You Can Tell How They Would Sound
Use No Distortion In The Humbucker To Single Coil Sound
And Use Distortion In The Single Coil To Humbucker Sound
Heres a List Of Them EQ's
http://www.samedaymusic.com/browse--Guitar-EQ--2613 
