Eric Claptons guitar tone in the 1960s....

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I'd try one part amp: Original Model 1962 50-watt 1962 Combo aka 'Bluesbreaker'

One part guitar: Real 1958, 1959, or 1960 Gibson Les Paul Standard (no one, even Clapton himself, knows for sure which year. I'd speculate though, based on descriptions he's made about the neck profile, that's it's most likely a 1960.)

One part 'big' money: About $50,000 to $250,000 depending on the Les Paul year and 'flamynous' (don't try that word in scrabble), and what kind of shape the vintage 1962 50-watt Combo you choose is in.

Most important ingrediant: Eric Clapton's talent

I thought he was playing an 18 watt 2x10 combo on that LP.

From what I understand he used a Dallas Rangemaster treble booster with his JTM45 Marshall and Gibson. Rangemaster's are very rare although there is a cottage industry of people making boutique copies:
http://www.treblebooster.com/eric_clapton.htm

also check out the Beano treble booster (a little more versatile):

Mom, is that you...

Nope it was a 50 watt 1962 combo

Not exact, but a close facsimile...

Frank G.