Ya hadda ask.
I've been playing a Hendrix Tribute Strat (a '68 reissue made in '97) as my main ax since '98, and I love it. This is a left-handed guitar, set up for a right-handed player, the mirror image of the guitar he played most during the last year or so of his life (the one in 'Woodstock'

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There is NO difference in the string tension because of the different string lengths beyond the nut. This is a complete myth. Tell your friends.
The tuners on the bottom side of the head are a bit awkward at first, but you get used to them pretty quickly. Restringing is also a bit clumsy; the easiest way is to wear the guitar on its strap, and face the guitar towards you.
One concession they did make on this guitar is to put the little position dots on the upper side of the neck for a right-handed player, and I'm glad they did!
The balance is just a bit neck-heavy because the strap button is mounted to a shorter bout. This would be annoying if one were to use a slippery nylon strap, but with a decent leather strap, it's not a problem at all. Sitting down and playing it resting on your leg presents no problem.
Access to the upper frets is rather limiting, but really no worse than a Les Paul. Hendrix's long fingers could reach all the way up to the last fret, but I sure can't. It's better if I don't spend much time playing those 'mouse notes' anyway.
I like the vibrato handle coming off the top side of the bridge assembly better than the regular way. I believe my hand can find it easier.
And I actually like the volume control on the top side better. On a regular Strat, I am constantly bumping the volume off; not a problem here. The middle pup tone control is a bit in the way of your forearm, though, and that is constantly being turned down inadvertently. I should just take it out of there, as I never use it anyway.
But overall, I like the guitar just fine. It has its quirks, but is remarkably comfortable. It constantly reminds me that, while I still can't play like Jimi, at least the guitar is no excuse! It definitely gets some looks, and allows me to feel a bit unique.
By the time he was well-known, Hendrix undoubtedly could have had a left-handed version made of anything he wanted (Gibson made him a real nice left-handed V), but the upside-down Strat had become a part of his unique image, and that can indeed be a valuable thing to consider.
And, it may be just a bit more collectable than any other Strat in its price range. They didn't sell all that well, and Fender stopped making them after a year or so. I got mine at dealer cost because the store needed to move it.
The same store sold me a Rick 331 Light Show Stereo for $200 back in '72, because it was just too weird for anyone else.
Except me, of course...